Hormones that influence in sperm production

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Spermatogenesis is a concerted sequence of events during maturation of spermatogonia into spermatozoa. The process involves differential gene-expression and cell-cell interplay regulated by the key endocrine stimuli, i. FSH affects independently and in concert with testosterone, the proliferation, maturation and function of the supporting Sertoli cells that produce regulatory signals and nutrients for the maintenance of developing germ cells. Rodents are able to complete spermatogenesis without FSH stimulus, but its deficiency significantly decreases sperm quantity. Men carrying loss-of-function mutation in the gene encoding the ligand FSHB or its receptor FSHR present, respectively, with azoospermia or suppressed spermatogenesis. Recently, the importance of high intratesticular testosterone concentration for spermatogenesis has been questioned.
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Circulating sex hormone levels in relation to male sperm quality

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Circulating sex hormone levels in relation to male sperm quality | BMC Urology | Full Text

Metrics details. Although sex hormones play critical roles in spermatogenesis and sperm maturation, it remains inconclusive whether circulating sex hormones can serve as non-invasive biomarkers to improve the assessment of sperm quality. We systematically evaluated the association of various sex hormones in serum with sperm quality among men in subfertile couples. Free testosterone and estradiol were calculated using a validated algorithm. A generalized liner regression model controlling for lifestyle factors was used to evaluate the associations with sperm count, concentration, motility, and morphology. Increased levels of LH are associated with poor sperm motility and morphology, suggesting that LH may play a central role in sperm maturation. Future studies are warranted to assess potential clinical utility of LH for risk stratification and tailed prevention of male infertility.
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Role of Follicle-Stimulating Hormone in Spermatogenesis

Sperm production is hormonally driven. Brain hormones govern sperm production and are precisely controlled. The male genitalia are responsible for sperm and ejaculate production. Within the brain, the hypothalamus and anterior pituitary control sperm production. The hypothalamus secretes gonadotropin-releasing hormone GnRH , which acts on the anterior pituitary gland, stimulating it to release follicle stimulating hormone FSH and leutinizing hormone LH.
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The onset of puberty is controlled by two major hormones: FSH initiates spermatogenesis and LH signals the release of testosterone. Puberty is a period of several years in which rapid physical growth and psychological changes occur, culminating in sexual maturity. The average onset of puberty is age 11 or 12 for boys. These changes are largely influenced by hormonal activity. Hormones play an organizational role, priming the body to behave in a certain way once puberty begins, and an activational role, referring to changes in hormones during adolescence that trigger behavioral and physical changes.
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